Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269724 | 1.00 | NPC1 (0.38) | NPC1RAB9ADDB1CRBNHPGD | |
| SCHEMBL7278830 | 0.76 | POLB (0.36) | KDM4CKMT2AMEN1GRM5HTT | |
| SCHEMBL7278836 | 0.76 | POLB (0.36) | KDM4CKMT2AMEN1GRM5HTT | |
| SCHEMBL7371558 | 0.75 | SMN1; SMN2 (0.43) | NPC1RAB9AHPGDRECQLKMT2A | |
| SCHEMBL7371560 | 0.75 | SMN1; SMN2 (0.43) | NPC1RAB9AHPGDRECQLKMT2A | |
| SCHEMBL7300104 | 0.75 | ADORA2B (0.40) | NPC1HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL7285419 | 0.75 | ADORA2B (0.40) | NPC1HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL7269604 | 0.75 | ADORA2B (0.40) | NPC1HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL7269607 | 0.75 | ADORA2B (0.40) | NPC1HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL7267634 | 0.73 | HPGD (0.39) | NPC1RAB9AHPGDRECQLKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |