Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285419 | 1.00 | ADORA2B (0.40) | ADORA2BGAACHRM5CHRM3CHRM1 | |
| SCHEMBL7269607 | 1.00 | ADORA2B (0.40) | ADORA2BGAACHRM5CHRM3CHRM1 | |
| SCHEMBL7269604 | 1.00 | ADORA2B (0.40) | ADORA2BGAACHRM5CHRM3CHRM1 | |
| SCHEMBL7361604 | 0.78 | ADORA2B (0.38) | ADORA2BKDM4EL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL7361609 | 0.78 | ADORA2B (0.38) | ADORA2BKDM4EL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL7321057 | 0.78 | ADORA2B (0.38) | ADORA2BKDM4EL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL7269724 | 0.75 | NPC1 (0.38) | KDM4EMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL7269729 | 0.75 | NPC1 (0.38) | KDM4EMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL7298926 | 0.75 | S1PR1 (0.35) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL7298920 | 0.75 | S1PR1 (0.35) | CHRM5CHRM3CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459131-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1995-10-17 | — | — | US | disclosed |
| US-5189023-A | Hypotensive agent | AMERICAN CYANAMID COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0473936-A1 | Renin Inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-03-11 | — | — | EP | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |