Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 10/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7272578 | 0.97 | ALDH1A1 (0.50) | L3MBTL3L3MBTL1ALDH1A1KDM4EPOLB | |
| Bicarbonate SCHEMBL19689366 | 0.90 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1ALDH1A1KDM4EPOLB | |
| Bicarbonate SCHEMBL11101479 | 0.90 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1ALDH1A1KDM4EPOLB | |
| SCHEMBL35282 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL10514755 | 0.82 | — | — | |
| SCHEMBL29586137 | 0.82 | L3MBTL3 (0.44) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL30952478 | 0.82 | — | — | |
| SCHEMBL29190841 | 0.82 | — | — | |
| Phosphoric Acid SCHEMBL28497432 | 0.81 | L3MBTL3 (0.44) | L3MBTL3L3MBTL1POLBMBTD1TP53BP1 | |
| Acetic Acid SCHEMBL11275843 | 0.80 | MEN1 (0.47) | L3MBTL3L3MBTL1ALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079022-A2 | Derivatives of cis, endo-2-azabicyclo-(3.3.0)-octane-3-carboxylic acid, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-05-18 | — | — | EP | disclosed |