Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | FNTA | P49354 | 1/20 | 0.59 |
| ▸ | FNTB | P49356 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indolylpropionic Acid SCHEMBL195405 | 0.87 | MAPT (0.68) | KMT2AMEN1MAPTALDH1A1HPGD | |
| Indolylpropionic Acid SCHEMBL29521227 | 0.87 | MAPT (0.68) | KMT2AMEN1MAPTALDH1A1HPGD | |
| Indolylpropionic Acid SCHEMBL29374161 | 0.87 | MAPT (0.68) | KMT2AMEN1MAPTALDH1A1HPGD | |
| Indolylpropionic Acid SCHEMBL2115660 | 0.85 | MAPT (0.66) | KMT2AMEN1MAPTALDH1A1HPGD | |
| Indolylpropionic Acid SCHEMBL29272702 | 0.85 | MAPT (0.66) | KMT2AMEN1MAPTALDH1A1HPGD | |
| Indolylpropionic Acid SCHEMBL2115658 | 0.84 | MAPT (0.64) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL125249 | 0.83 | MEN1 (1.00) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL28378507 | 0.83 | MAPT (0.68) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL29362070 | 0.83 | MEN1 (1.00) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL27763159 | 0.83 | MEN1 (1.00) | KMT2AMEN1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5348944-A | Hypotensive agents | SCHERING CORPORATION (US) | 1994-09-20 | — | — | US | disclosed |
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0073143-B1 | NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES | Ryan, James Walter (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0073143-A2 | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides | Ryan, James Walter (US) | 1983-03-02 | — | — | EP | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0050800-A1 | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1982-05-05 | — | — | EP | disclosed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |