Indolylpropionic Acid

Indolylpropionic Acid

SCHEMBL2115658

O=C([O-])CCc1c[nH]c2ccccc12.O=C([O-])CCc1c[nH]c2ccccc12.[Ca+2]

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Indolylpropionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.64
ALDH1A1 P00352 4/20 0.64
GAA P10253 1/20 0.64
KMT2A Q03164 6/20 0.58
HPGD P15428 2/20 0.58
HTT P42858 1/20 0.58
RECQL P46063 1/20 0.58
PDPK1 O15530 1/20 0.58
MEN1 O00255 5/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
KDM4E B2RXH2 1/20 0.58
CYP1A2 P05177 2/20 0.56
LMNA P02545 2/20 0.56
PKM P14618 1/20 0.56
TSHR P16473 1/20 0.56
CYP2C19 P33261 1/20 0.56
BLM P54132 1/20 0.56
MPO P05164 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithium Ion SCHEMBL3886259 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
Zinc Ion SCHEMBL29272700 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
Potassium Ion SCHEMBL29437204 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
SCHEMBL29272529 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
SCHEMBL29272547 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
SCHEMBL29596613 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
SCHEMBL3886757 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
Potassium Ion SCHEMBL584105 0.88 KMT2A (0.64) MAPTALDH1A1GAAKMT2AHPGD
SCHEMBL7270097 0.84 KMT2A (0.71) MAPTALDH1A1GAAKMT2AHPGD
Indolylpropionic Acid SCHEMBL195405 0.83 MAPT (0.68) MAPTALDH1A1GAAKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061459-B1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC (US) 2012-12-26 EP claimed
US-20120095071-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2012-04-19 US claimed
US-20100317710-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2010-12-16 US claimed
EP-2061459-A2 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM Intellect Neurosciences Inc. (US) 2009-05-27 EP claimed
US-20080207731-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES, INC. (US) 2008-08-28 US claimed
WO-2008024914-A2 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2008-02-28 WO claimed
EP-2061459-B1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC (US) 2012-12-26 EP disclosed
EP-2061459-B1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC (US) 2012-12-26 EP disclosed
US-20120095071-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2012-04-19 US disclosed
US-20120095071-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2012-04-19 US disclosed
US-20100317710-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2010-12-16 US disclosed
US-20100317710-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2010-12-16 US disclosed
EP-2061459-A4 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC (US) 2010-05-26 EP disclosed
US-20080207731-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES, INC. (US) 2008-08-28 US disclosed
US-20080207731-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES, INC. (US) 2008-08-28 US disclosed
WO-2008024914-A3 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC (US) 2008-08-14 WO disclosed
WO-2008024914-A3 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC (US) 2008-08-14 WO disclosed
WO-2008024914-A2 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2008-02-28 WO disclosed
WO-2008024914-A2 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2008-02-28 WO disclosed
WO-2008024914-A2 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM INTELLECT NEUROSCIENCES INC. (US) 2008-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317710-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM ORAI1, SARAF, ORAI3 MAPT 243/4885ALDH1A1 2897/4885GAA 3093/4885
US-20120095071-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM ORAI1, SARAF, ORAI3 MAPT 243/4885ALDH1A1 2897/4885GAA 3093/4885
US-20080207731-A1 3-(3-INDOLYL) PROPIONIC ACID CALCIUM SALT AND METHOD OF MAKING 3-(3-INDOLYL) PROPIONIC ACID FREE ACID THEREFROM ORAI1, SARAF, ORAI3 MAPT 243/4885ALDH1A1 2897/4885GAA 3093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.