Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270836 | 0.88 | ADORA2B (0.60) | ADORA1ADORA2BADORA2AADORA3SLC6A3 | |
| SCHEMBL7268807 | 0.81 | ADORA2A (0.61) | ADORA1ADORA2BADORA2AADORA3SLC6A3 | |
| SCHEMBL7276131 | 0.79 | ADORA2A (0.59) | ADORA1ADORA2BADORA2AADORA3SLC6A3 | |
| SCHEMBL7268943 | 0.79 | ADORA3 (0.53) | ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7269366 | 0.74 | ADORA1 (1.00) | ADORA1ADORA2BADORA2AADORA3SLC6A3 | |
| SCHEMBL7758386 | 0.74 | ADORA3 (0.48) | ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7758347 | 0.74 | ADORA3 (0.48) | ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL14903094 | 0.73 | ADORA1 (0.86) | ADORA1ADORA2BADORA2AADORA3SLC6A3 | |
| SCHEMBL7761664 | 0.72 | ADORA3 (0.46) | ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7760157 | 0.72 | ADORA3 (0.46) | ADORA1ADORA2BADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415456-B1 | Xanthine compounds | KYOWA HAKKO KOGYO KK (JP) | 1996-06-26 | — | — | EP | disclosed |
| US-5525607-A | DIURETICS, BRONCHODILATORS, RENAL PROTECTING AGENTS | KYOWA HAKKO KOGYO CO., LTD (JP) | 1996-06-11 | — | — | US | disclosed |
| US-5290782-A | Bronchodilator agents, diuretics for renal protective agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| EP-0415456-A2 | Xanthine compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |