Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968208 | 0.83 | TLR8 (0.45) | AGTR1AGTR2APLNRALDH1A1TLR8 | |
| SCHEMBL7216579 | 0.81 | TLR8 (0.41) | APLNRALDH1A1TLR8LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL7631242 | 0.80 | HTR2A (0.40) | APLNRALDH1A1TLR8LMNAKDM4E | |
| SCHEMBL27748327 | 0.78 | TSHR (0.42) | PDE4BAPLNRALDH1A1LMNAMAPK1 | |
| SCHEMBL9856773 | 0.78 | ALDH1A1 (0.46) | APLNRALDH1A1TLR8LMNAKDM4E | |
| SCHEMBL4542850 | 0.77 | LMNA (0.42) | AGTR1AGTR2ALDH1A1LMNAKDM4E | |
| SCHEMBL7270020 | 0.75 | ALDH1A1 (0.41) | AGTR1AGTR2APLNRALDH1A1TLR8 | |
| SCHEMBL9857429 | 0.74 | SCN3A (0.44) | — | |
| SCHEMBL9856774 | 0.73 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL27461046 | 0.73 | ALDH1A1 (0.42) | APLNRALDH1A1TLR8LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992002510-A1 | SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |
| EP-0425211-A1 | Substituted 5-((tetrazolyl)alkenyl)-imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-05-02 | — | — | EP | disclosed |
| EP-0403159-A2 | Imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |