Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1522773 | 0.87 | FEN1 (0.55) | CYP2C19ALDH1A1KAT2BTSHRFEN1 | |
| SCHEMBL7278555 | 0.85 | POLB (0.43) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL7278394 | 0.85 | LMNA (0.51) | ALDH1A1KAT2BPDE4BNPC1RAB9A | |
| SCHEMBL7281964 | 0.78 | HPGD (0.53) | HPGDCYP2C19CYP1A2ALDH1A1TSHR | |
| SCHEMBL7281855 | 0.78 | KAT2B (0.50) | HPGDCYP1A2ALDH1A1KAT2BPDE4B | |
| SCHEMBL2412984 | 0.77 | KMT2A (0.55) | HPGDCYP2C19CYP1A2ALDH1A1TSHR | |
| SCHEMBL1522225 | 0.77 | PTGDR2 (0.55) | HPGDALDH1A1KAT2BSMN1; SMN2TP53 | |
| SCHEMBL11240235 | 0.75 | FEN1 (0.51) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL2409225 | 0.73 | PDE4A (0.57) | ALDH1A1KAT2BPDE4BPDE4APDE4C | |
| SCHEMBL11978691 | 0.73 | CYP2C19 (0.49) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |