Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2412984 | 0.85 | KMT2A (0.55) | HPGDMAPTCYP2C19KMT2AMEN1 | |
| SCHEMBL7278555 | 0.85 | POLB (0.43) | HPGDCYP2C19KMT2AMEN1CYP1A2 | |
| SCHEMBL1522773 | 0.84 | FEN1 (0.55) | MAPTCYP2C19KMT2AALDH1A1KDM4E | |
| SCHEMBL7281855 | 0.83 | KAT2B (0.50) | HPGDMAPTKMT2ACYP1A2ALDH1A1 | |
| SCHEMBL2409225 | 0.81 | PDE4A (0.57) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL7270906 | 0.78 | HPGD (0.51) | HPGDCYP2C19KMT2AMEN1CYP1A2 | |
| SCHEMBL1522402 | 0.77 | PTGDR2 (0.55) | HPGDMAPTCYP2C19KMT2AMEN1 | |
| SCHEMBL5249954 | 0.76 | HPGD (0.64) | HPGDMAPTCYP2C19KMT2AMEN1 | |
| SCHEMBL7278394 | 0.75 | LMNA (0.51) | MAPTKMT2AALDH1A1KDM4EPDE4B | |
| SCHEMBL9132147 | 0.74 | MAPT (0.52) | HPGDMAPTCYP2C19KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |