Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.31 |
| ▸ | MMP9 | P14780 | 3/20 | 0.31 |
| ▸ | MMP7 | P09237 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8681880 | 0.87 | PRSS1 (0.34) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7282942 | 0.78 | MMP1 (0.32) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7290039 | 0.78 | MMP1 (0.32) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7337078 | 0.76 | CTSD (0.35) | — | |
| SCHEMBL7292526 | 0.74 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL8908161 | 0.74 | KDM6B (0.32) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL9417461 | 0.74 | KDM6B (0.32) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7270999 | 0.74 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL9222144 | 0.74 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL8908550 | 0.74 | KDM6B (0.32) | MMP1MMP9MMP7MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360791-A | Renin-inhibiting aminodiol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0370454-B1 | Renin-inhibiting amino diol derivatives | HOECHST AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |