Questiomycin B

Questiomycin B

SCHEMBL727121

Nc1ccccc1O.O=P(O)(O)O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Questiomycin B. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.75
TSHR P16473 2/20 0.75
MAPT P10636 4/20 0.43
ALDH1A1 P00352 4/20 0.43
CYP3A4 P08684 3/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 3/20 0.43
HSD17B10 Q99714 3/20 0.43
CA2 P00918 3/20 0.43
CA4 P22748 3/20 0.43
CA5A P35218 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 2/20 0.43
CA12 O43570 2/20 0.43
CA14 Q9ULX7 2/20 0.43
CA5B Q9Y2D0 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Questiomycin B SCHEMBL5570900 0.98 ALOX15 (0.71) ALOX15TSHRMAPTALDH1A1CYP3A4
Questiomycin B SCHEMBL28175336 0.98 ALOX15 (0.71) ALOX15TSHRMAPTALDH1A1CYP3A4
Questiomycin B SCHEMBL3999786 0.87 ALOX15 (1.00) ALOX15TSHRMAPTALDH1A1CYP3A4
Questiomycin B SCHEMBL24436 0.87
Questiomycin B SCHEMBL29430322 0.87
Questiomycin B SCHEMBL1823522 0.84 ALOX15 (0.83) ALOX15TSHRMAPTALDH1A1CYP3A4
SCHEMBL18612812 0.84 ALOX15 (0.94) ALOX15TSHRMAPTALDH1A1CYP3A4
Questiomycin B SCHEMBL4747619 0.84 ALOX15 (0.94) ALOX15TSHRMAPTALDH1A1CYP3A4
Questiomycin B SCHEMBL3887270 0.84
Questiomycin B SCHEMBL15436150 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4396587-A1 METHODS AND SYSTEMS OF DIAGNOSING BRAIN INJURY Abbott Laboratories (US) 2024-07-10 EP disclosed
EP-4356129-A1 METHODS OF DIAGNOSING OR AIDING IN DIAGNOSIS OF BRAIN INJURY CAUSED BY ACOUSTIC ENERGY, ELECTROMAGNETIC ENERGY, AN OVER PRESSURIZATION WAVE, AND/OR BLAST WIND Abbott Laboratories (US) 2024-04-24 EP disclosed
CN-117466970-A Synthesis and preparation method of novel compound phenylphosphoric amino peptide for promoting plant rooting and growth 蒋仕荣 2024-01-30 CN disclosed
EP-4193149-A1 IMPROVED METHODS AND KITS FOR DETECTING SARS-COV-2 PROTEIN IN A SAMPLE Abbott Laboratories (US) 2023-06-14 EP disclosed
WO-2023034777-A1 METHODS AND SYSTEMS OF DIAGNOSING BRAIN INJURY ABBOTT LABORATORIES (US) 2023-03-09 WO disclosed
WO-2022266034-A1 METHODS OF DIAGNOSING OR AIDING IN DIAGNOSIS OF BRAIN INJURY CAUSED BY ACOUSTIC ENERGY, ELECTROMAGNETIC ENERGY, AN OVER PRESSURIZATION WAVE, AND/OR BLAST WIND ABBOTT LABORATORIES (US) 2022-12-22 WO disclosed
EP-3965641-A1 EVALUATING BIOMARKERS ALONG WITH ADVANCED MAGNETIC RESONANCE IMAGING PROCEDURES IN A HUMAN SUBJECT THAT HAS SUSTAINED OR MAY HAVE SUSTAINED A HEAD INJURY Abbott Laboratories (US) 2022-03-16 EP disclosed
WO-2020231846-A1 EVALUATING BIOMARKERS ALONG WITH ADVANCED MAGNETIC RESONANCE IMAGING PROCEDURES IN A HUMAN SUBJECT THAT HAS SUSTAINED OR MAY HAVE SUSTAINED A HEAD INJURY ABBOTT LABORATORIES (US) 2020-11-19 WO disclosed
EP-3732489-A1 NOVEL BIOMARKERS AND METHODS FOR DIAGNOSING AND EVALUATING TRAUMATIC BRAIN INJURY Abbott Laboratories (US) 2020-11-04 EP disclosed
EP-3673079-A1 SENSOR APPARATUS AND METHOD FOR TESTING A SAMPLE Boehringer Ingelheim Vetmedica GmbH (DE) 2020-07-01 EP disclosed
US-6423251-B1 FIREPROOFING BLOUNT DAVID H (US) 2002-07-23 US disclosed
US-6423250-B1 FIREPROOFING ORGANIC COMPOUNDS WITH CYANURIC ACID AND CYAMELIDE AND ALDEHYDE RESIN BLOUNT DAVID H (US) 2002-07-23 US disclosed
US-6348526-B1 FIREPROOFING WITH UREA POLYMERS BLOUNT DAVID H (US) 2002-02-19 US disclosed
US-6270694-B1 PRODUCT FROM REACTED UREA, ORGANIC COMPOUND, WATER, CARBONIZATION AUXILIARIES, ALDEHYDE AND FILLER BLOUNT DAVID H (US) 2001-08-07 US disclosed
US-6258298-B1 REDUCING COMBUSTIBILITY OF ORGANIC MATERIAL COMPRISING INCORPORATING AND AMINO CONDENSATION COMPOUND AND/OR COMPOSITION WITH THE ORGANIC MATERIAL, UNDER REACTION AND/OR MIXING CONDITIONS OF THE ORGANIC MATERIAL BLOUNT DAVID H (US) 2001-07-10 US disclosed
US-5547810-A EXPOSING SILVER HALIDE LIGHT SENSITIVE MATERIAL CONTAINING METAL COMPOUND, SUPERPOSING ON IMAGE RECEIVING MATERIAL CONTAINING COMPLEX FORMING COMPOUND, HEATING IN PRESENCE OF WATER, SEPARATING KONICA CORPORATION (JP) 1996-08-20 US disclosed
EP-0656562-A2 Diffusion transfer heat processable photosensitive material KONICA CORPORATION (JP) 1995-06-07 EP disclosed
US-5292611-A Dye image forming method KONICA CORPORATION (JP) 1994-03-08 US disclosed
US-5223384-A Multilayer; paper support, subbing and photosensitive layer KONICA CORPORATION (JP) 1993-06-29 US disclosed
EP-0547606-A1 Dye image forming method KONICA CORPORATION (JP) 1993-06-23 EP disclosed