Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10745905 | 0.88 | AMY1A (0.53) | AMY1APDE2APDGFRBPDGFRAMAPT | |
| SCHEMBL11021153 | 0.88 | PDE2A (0.46) | AMY1APDE2APDGFRBPDGFRAMAPT | |
| SCHEMBL11019408 | 0.88 | AMY1A (0.46) | AMY1APDE2APDGFRBPDGFRAMAPT | |
| SCHEMBL10760424 | 0.86 | PDE2A (0.44) | AMY1APDE2APDGFRBPDGFRAMAPT | |
| SCHEMBL10763231 | 0.84 | NPBWR1 (0.43) | PDE2APDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL25885094 | 0.83 | AMY1A (0.46) | AMY1APDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL7271892 | 0.83 | PDE5A (0.51) | PDE2APDGFRBPDGFRAMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL9636258 | 0.82 | PDE5A (0.52) | PDE2APDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL11019179 | 0.82 | AMY1A (0.47) | AMY1APDE2APDGFRBPDGFRAPDE5A | |
| SCHEMBL11018423 | 0.82 | AMY1A (0.47) | AMY1APDE2ANPSR1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |