Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.61 |
| ▸ | MME | P08473 | 5/20 | 0.56 |
| ▸ | PTGES | O14684 | 2/20 | 0.56 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CPA1 | P15085 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | FPR2 | P25090 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030332 | 0.89 | MME (0.68) | PTPN1MMELPAR1ACENPSR1 | |
| SCHEMBL8030328 | 0.89 | MME (0.68) | PTPN1MMELPAR1ACENPSR1 | |
| SCHEMBL7272209 | 0.86 | MME (0.57) | PTPN1MMELPAR1ACENPSR1 | |
| SCHEMBL9554306 | 0.85 | ATM (0.60) | PTGESALDH1A1L3MBTL1 | |
| SCHEMBL9007746 | 0.84 | MME (0.77) | PTPN1MMEACECPA1ACE2 | |
| SCHEMBL9007742 | 0.84 | MME (0.77) | PTPN1MMEACECPA1ACE2 | |
| SCHEMBL8017424 | 0.82 | MME (0.57) | PTPN1MMELPAR1ACEL3MBTL1 | |
| SCHEMBL8017421 | 0.82 | MME (0.57) | PTPN1MMELPAR1ACEL3MBTL1 | |
| SCHEMBL16195620 | 0.82 | MME (0.58) | PTPN1MMEACENPSR1NAALAD2 | |
| SCHEMBL9554773 | 0.81 | PTPN1 (0.57) | PTPN1MMEACENPSR1NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0386611-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-12 | — | — | EP | disclosed |
| EP-0310918-A2 | Peptide-like amino-acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-12 | — | — | EP | disclosed |