Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.52 |
| ▸ | ACE | P12821 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.49 |
| ▸ | CPA1 | P15085 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272209 | 0.90 | MME (0.57) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL14398153 | 0.81 | MME (0.49) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL9554565 | 0.80 | PTPN1 (0.61) | MMEACENPSR1ACE2CPA1 | |
| SCHEMBL16195620 | 0.78 | MME (0.58) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL7266724 | 0.76 | MEN1 (0.60) | ACE | |
| SCHEMBL7275396 | 0.76 | MME (0.56) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL7278010 | 0.76 | MME (0.56) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL7356137 | 0.74 | MME (0.51) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL19974071 | 0.74 | L3MBTL1 (0.60) | MMEACENPSR1LMNAACE2 | |
| SCHEMBL9554773 | 0.74 | PTPN1 (0.57) | MMEACENPSR1ACE2CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |