Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263514 | 0.84 | MAPT (0.45) | MAPK1ALDH1A1TDP1L3MBTL1HTT | |
| SCHEMBL7264081 | 0.83 | ALDH3A1 (0.40) | MAPK1ALDH1A1TDP1L3MBTL1HTT | |
| SCHEMBL7263524 | 0.83 | VCAM1 (0.52) | MAPK1ALDH1A1TDP1L3MBTL1HTT | |
| SCHEMBL7263522 | 0.83 | KDM4E (0.41) | MAPK1L3MBTL1HTTEGFRMEN1 | |
| SCHEMBL10991410 | 0.83 | HTT (0.38) | ALDH1A1L3MBTL1HTTMAPTMEN1 | |
| SCHEMBL7263501 | 0.83 | VCAM1 (0.49) | MAPK1ALDH1A1TDP1L3MBTL1HTT | |
| SCHEMBL7272454 | 0.82 | POLB (0.38) | MAPK1ALDH1A1TDP1HTTMAPT | |
| SCHEMBL7272347 | 0.80 | MAPK1 (0.52) | MAPK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7271277 | 0.80 | MERTK (0.45) | ALDH1A1TDP1L3MBTL1HTTMAPT | |
| SCHEMBL11000243 | 0.80 | MAPK1 (0.46) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4542131-A | NERVOUS SYSTEM DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1985-09-17 | — | — | US | disclosed |
| US-4486591-A | CNS DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1984-12-04 | — | — | US | disclosed |
| US-4404137-A | NEUROLEPTIC AGENTS; SEDATIVES; TRANQUILIZERS; ANTIEMETICS | LILLY INDUSTRIES LIMITED (GB) | 1983-09-13 | — | — | US | disclosed |
| EP-0027390-A1 | Novel benzodiazepine compounds, their preparation, intermediates employed in their preparation, and pharmaceutical compositions containing them | Lilly Industries Limited (GB) | 1981-04-22 | — | — | EP | disclosed |