Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279582 | 0.89 | FEN1 (0.53) | ALDH1A1CYP2C19HTTFEN1PDE4A | |
| SCHEMBL7281424 | 0.87 | PKM (0.49) | ALDH1A1HPGDHTTKAT2BMAPT | |
| SCHEMBL7272450 | 0.87 | ALDH1A1 (0.47) | ALDH1A1HPGDHTTFEN1PDE4A | |
| SCHEMBL7271437 | 0.86 | ALDH1A1 (0.45) | ALDH1A1CYP2C9CYP1A2HPGDCYP2C19 | |
| SCHEMBL7272901 | 0.81 | PDE4A (0.48) | ALDH1A1CYP1A2HPGDCYP2C19HTT | |
| SCHEMBL7282270 | 0.81 | KAT2B (0.47) | ALDH1A1HPGDHTTKAT2BPDE4A | |
| SCHEMBL30541541 | 0.80 | FEN1 (0.50) | ALDH1A1CYP2C9CYP2C19HTTFEN1 | |
| SCHEMBL11371962 | 0.80 | FEN1 (0.50) | ALDH1A1CYP2C9CYP2C19HTTFEN1 | |
| SCHEMBL11365339 | 0.79 | FEN1 (0.49) | ALDH1A1CYP2C9CYP2C19HTTFEN1 | |
| SCHEMBL11365344 | 0.79 | FEN1 (0.49) | ALDH1A1HTTFEN1PDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |