Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 11/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946930 | 0.73 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8CACNA1B | |
| SCHEMBL7434314 | 0.73 | MTOR (0.53) | MTORRAB9AABCC9ABCC8KCNJ11 | |
| SCHEMBL6950055 | 0.73 | POLB (0.49) | MTORCACNA1BGAAKDM4EALDH1A1 | |
| SCHEMBL6953639 | 0.72 | GAA (0.45) | MTORABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8700129 | 0.71 | GAA (0.54) | MTORCACNA1BGAAKDM4EALDH1A1 | |
| SCHEMBL8949674 | 0.70 | CACNA1F (0.53) | RAB9AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7266318 | 0.69 | CACNA1B (0.36) | MTORRAB9AABCC9ABCC8KCNJ11 | |
| SCHEMBL8699921 | 0.69 | CACNA1B (0.65) | CACNA1B | |
| SCHEMBL7157076 | 0.67 | NR1I2 (0.50) | MTORRAB9ACACNA1BGAAKDM4E | |
| SCHEMBL7410687 | 0.67 | CACNA1B (0.61) | CACNA1BGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0174131-A2 | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them | FISONS plc (GB) | 1986-03-12 | — | — | EP | claimed |
| EP-0174131-A2 | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them | FISONS plc (GB) | 1986-03-12 | — | — | EP | disclosed |