Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953639 | 0.87 | GAA (0.45) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL27673576 | 0.85 | MAPT (0.56) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL6950016 | 0.84 | ALOX15 (0.50) | ALDH1A1KDM4ECACNA1BCACNA1FADORA3 | |
| SCHEMBL27544295 | 0.83 | TSHR (0.46) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL8222248 | 0.83 | GAA (0.43) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL2615091 | 0.83 | NR1I2 (0.65) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL29676427 | 0.83 | NR1I2 (0.65) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL2615090 | 0.83 | NR1I2 (0.65) | GAANR1I2ALDH1A1KDM4ECACNA1B | |
| SCHEMBL9235674 | 0.82 | CACNA1B (0.46) | CACNA1BCACNA1FADORA3CACNA1DCACNA1S | |
| SCHEMBL3027183 | 0.80 | ADORA3 (0.59) | GAANR1I2ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7196614-A | — | — | None | — | — | JP | disclosed |
| CN-114516774-A | Preparation method of chiral bromo-1, 4-dihydropyridine compound | 中国科学院成都生物研究所 | 2022-05-20 | — | — | CN | disclosed |
| CN-1089337-C | 1, 4-dihydropyridine derivatives | MERCIAN CORP (JP) | 2002-08-21 | — | — | CN | disclosed |
| US-5760238-A | ANTIISCHEMIC AGENTS | MERCIAN CORPORATION (JP) | 1998-06-02 | — | — | US | disclosed |
| CN-1156450-A | 1,4-dihydropyridine derivatives | MERCIAN CORP (JP) | 1997-08-06 | — | — | CN | disclosed |
| JP-H07196614-A | PHENYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE | BAYER AG | 1995-08-01 | — | — | JP | disclosed |
| US-4699984-A | Preparation of intermediates to 6-fluoro-7-(2,6-dimethylpyridyl)quinoline carboxylic acids and compounds | STERLING DRUG INC. (US) | 1987-10-13 | — | — | US | disclosed |
| EP-0179239-A2 | 7-(Pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid having antibacterial activity and preparation thereof | STERLING DRUG INC. (US) | 1986-04-30 | — | — | EP | disclosed |