Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.39 |
| ▸ | METAP2 | P50579 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280572 | 1.00 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7280466 | 1.00 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7385184 | 1.00 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7385187 | 1.00 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382092 | 0.99 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382344 | 0.99 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7376798 | 0.99 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382336 | 0.99 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382340 | 0.99 | REN (0.39) | RENMETAP2METAP1 | |
| Acetic Acid SCHEMBL7290478 | 0.95 | REN (0.40) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483403-A1 | Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-4994477-A | Hypotensive agents | ABBOTT LABORATORIES (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |