Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.40 |
| ▸ | METAP2 | P50579 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385187 | 0.95 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7385184 | 0.95 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7280466 | 0.95 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7273148 | 0.95 | REN (0.39) | RENMETAP2METAP1 | |
| SCHEMBL7280572 | 0.95 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382340 | 0.94 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382336 | 0.94 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382092 | 0.94 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7376798 | 0.94 | REN (0.39) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7382344 | 0.94 | REN (0.39) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |