Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 9/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305830 | 1.00 | CTSS (0.47) | CTSSCTSKAAK1RENCYP3A4 | |
| SCHEMBL1867025 | 0.83 | CTSK (0.53) | CTSSCTSKAAK1RENCYP3A4 | |
| SCHEMBL4974388 | 0.83 | CTSK (0.53) | CTSSCTSKAAK1RENCYP3A4 | |
| SCHEMBL7375658 | 0.83 | CTSK (0.53) | CTSSCTSKAAK1RENCYP3A4 | |
| SCHEMBL7332961 | 0.83 | CTSK (0.53) | CTSSCTSKAAK1RENCYP3A4 | |
| SCHEMBL28848451 | 0.83 | CTSK (0.53) | CTSSCTSKAAK1RENCYP3A4 | |
| SCHEMBL2760591 | 0.82 | CA1 (0.40) | CTSSCTSKKMT2A | |
| SCHEMBL8270806 | 0.82 | CA1 (0.40) | CTSSCTSKKMT2A | |
| SCHEMBL2760527 | 0.82 | CA1 (0.40) | CTSSCTSKKMT2A | |
| SCHEMBL7289613 | 0.81 | GRN (0.35) | CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297816-B1 | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0321192-B1 | Non-peptidic renin inhibitors | PFIZER (US) | 1993-10-27 | — | — | EP | disclosed |
| EP-0552309-A1 | NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS | MERCK & CO. INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0550924-A1 | 2-Pyrrolidinone derivatives as HIV protease inhibitors | MERCK & CO. INC. (US) | 1993-07-14 | — | — | EP | disclosed |
| EP-0534511-A1 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0487270-A2 | HIV protease inhibitors having polyether substituents | MERCK & CO. INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| WO-1992006992-A2 | NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS | MERCK & CO., INC. (US) | 1992-04-30 | — | — | WO | disclosed |
| EP-0434365-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0326364-A2 | Renin inhibitory oligopeptides, their preparation and use | Sankyo Company Limited (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0297816-A2 | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents | PFIZER INC. (US) | 1989-01-04 | — | — | EP | disclosed |