Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | GALR3 | O60755 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266967 | 0.95 | GALR3 (0.73) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL10475489 | 0.85 | MAPT (0.74) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| Iodide SCHEMBL10474006 | 0.84 | MAPT (0.71) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL7266906 | 0.83 | GALR3 (0.79) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL7273931 | 0.83 | GALR3 (0.79) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL16157214 | 0.83 | MAPT (1.00) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| Iodide SCHEMBL10475201 | 0.82 | GALR3 (0.71) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL7266840 | 0.82 | SMN1; SMN2 (0.52) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL7267555 | 0.81 | GALR3 (0.81) | MAPTGALR3SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL7321514 | 0.80 | GALR3 (0.77) | MAPTGALR3SMN1; SMN2THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0327800-A2 | 6-Phenyldihydro-3(2H)-pyridazinones, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-08-16 | — | — | EP | disclosed |