Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951184 | 0.92 | CACNA1F (0.60) | CACNA1FCACNA1DCACNA1SCACNA1CNOTCH1 | |
| SCHEMBL7479725 | 0.87 | POLB (0.47) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7265857 | 0.86 | CACNA1B (0.53) | POLBLMNAGAACACNA1BNR3C2 | |
| SCHEMBL6137184 | 0.84 | CACNA1C (0.64) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7275834 | 0.84 | CACNA1F (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7265637 | 0.84 | CACNA1F (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7163595 | 0.84 | CACNA1F (0.73) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7265923 | 0.84 | ALDH1A1 (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7266695 | 0.83 | CACNA1F (0.49) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB | |
| SCHEMBL7267597 | 0.83 | CACNA1F (0.49) | CACNA1FCACNA1DCACNA1SCACNA1CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |