Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273476 | 0.87 | CACNA1F (0.53) | POLBGAALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7483319 | 0.86 | CACNA1B (0.50) | CACNA1B | |
| SCHEMBL7265857 | 0.86 | CACNA1B (0.53) | POLBGAALMNACACNA1BNR3C2 | |
| SCHEMBL7481235 | 0.85 | NR1I2 (0.46) | POLBGAALMNACACNA1BCACNA1F | |
| SCHEMBL7265923 | 0.84 | ALDH1A1 (0.58) | POLBGAALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7266695 | 0.83 | CACNA1F (0.49) | POLBGAALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7265997 | 0.82 | MAPT (0.58) | POLBLMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL7275995 | 0.80 | KDM4E (0.45) | POLBGAALMNAKDM4EALDH1A1 | |
| SCHEMBL4436094 | 0.80 | SMN1; SMN2 (0.49) | POLBGAALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7267666 | 0.80 | LMNA (0.49) | POLBGAALMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747357-B1 | Dihydropyridine NPY antagonists: piperidine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2002-01-09 | — | — | EP | disclosed |
| US-5668151-A | USEFUL AS ANOREXIGENIC AGENTS IN PROMOTING WEIGHT LOSS AND TREATING EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5635503-A | TREATMENT OF EATING DISORDERS, PROMOTING WEIGHT LOSS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-06-03 | — | — | US | disclosed |
| EP-0747357-A2 | Dihydropyridine NPY antagonists: piperidine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747378-A1 | Dihydropyridine NPY antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747356-A1 | Dihydropyridine NPY antagonists: piperazine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5554621-A | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-09-10 | — | — | US | disclosed |