Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 6/20 | 0.38 |
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274722 | 0.85 | GABBR2 (0.42) | HDAC1ALDH1A1RAB9AS1PR1 | |
| SCHEMBL7282206 | 0.83 | F10 (0.47) | F2F10PRSS1 | |
| SCHEMBL7281838 | 0.81 | HRH3 (0.44) | HDAC1LOXL2CTSGCMA1MAPT | |
| Hydrochloric Acid SCHEMBL7282229 | 0.80 | HRH3 (0.43) | HDAC1LOXL2CTSGCMA1MAPT | |
| Hydrochloric Acid SCHEMBL7275507 | 0.78 | MAPT (0.45) | HDAC1LOXL2ALDH1A1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL7272819 | 0.76 | HRH3 (0.44) | HDAC1LOXL2F2F10PRSS1 | |
| Hydrochloric Acid SCHEMBL7279879 | 0.76 | PTGS2 (0.43) | HDAC1LOXL2ALDH1A1RAB9A | |
| SCHEMBL7275290 | 0.75 | SIRT2 (0.42) | HDAC1LOXL2F2F10PRSS1 | |
| Hydrochloric Acid SCHEMBL7275455 | 0.74 | HRH3 (0.40) | HDAC1ALDH1A1MAPTS1PR1 | |
| SCHEMBL7283860 | 0.74 | S1PR1 (0.49) | HDAC1RAB9APKMS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |