Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881567 | 0.90 | MTNR1A (0.47) | MTNR1AMTNR1BTBXA2R | |
| SCHEMBL8296298 | 0.82 | MTNR1A (0.44) | MTNR1AMTNR1BTBXA2R | |
| SCHEMBL7281450 | 0.80 | MTNR1A (0.68) | MTNR1AMTNR1B | |
| SCHEMBL8730184 | 0.78 | MAPT (0.50) | MAPTNPC1RAB9ATBXA2RHSD17B1 | |
| SCHEMBL7276035 | 0.77 | MTNR1A (0.53) | MTNR1AMTNR1B | |
| SCHEMBL6641688 | 0.77 | NPC1 (0.49) | MAPTNPC1RAB9ATBXA2RHSD17B1 | |
| SCHEMBL10405252 | 0.76 | CA1 (0.61) | MTNR1AMTNR1BMAPTNPC1RAB9A | |
| SCHEMBL10978186 | 0.76 | MAPT (0.47) | MAPTNPC1RAB9ATBXA2RHSD17B1 | |
| SCHEMBL8733286 | 0.75 | TBXA2R (0.79) | TBXA2R | |
| SCHEMBL17513830 | 0.75 | MAPT (0.58) | MAPTNPC1RAB9AHSD17B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |