Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.52 |
| ▸ | METAP2 | P50579 | 4/20 | 0.43 |
| ▸ | METAP1 | P53582 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326084 | 0.86 | REN (0.52) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7328910 | 0.86 | REN (0.52) | RENMETAP2METAP1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL7324277 | 0.85 | REN (0.51) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL8682444 | 0.82 | REN (0.55) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL8682141 | 0.82 | REN (0.55) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7279876 | 0.82 | REN (0.55) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7327540 | 0.81 | REN (0.53) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7269766 | 0.80 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7268680 | 0.80 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7269758 | 0.80 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |