Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.47 |
| ▸ | METAP2 | P50579 | 7/20 | 0.39 |
| ▸ | METAP1 | P53582 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269766 | 1.00 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7268680 | 1.00 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7273715 | 0.80 | REN (0.52) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7326084 | 0.80 | REN (0.52) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7328910 | 0.80 | REN (0.52) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9554531 | 0.79 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL9554528 | 0.79 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL7292635 | 0.79 | REN (0.47) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7324277 | 0.78 | REN (0.51) | RENMETAP2METAP1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL9554876 | 0.78 | REN (0.46) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391180-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |