SCHEMBL7274085

SCHEMBL7274085

[N-]=[N+]=CC(=O)C(Cc1ccc2ccccc2c1)OC(N)=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.41
PPARA Q07869 2/20 0.41
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
MMP1 P03956 1/20 0.39
PPARD Q03181 1/20 0.39
SLC1A3 P43003 1/20 0.38
SLC1A2 P43004 1/20 0.38
SLC1A1 P43005 1/20 0.38
MC5R P33032 2/20 0.38
MC1R Q01726 2/20 0.38
MMP9 P14780 2/20 0.38
FCER2 P06734 2/20 0.38
MMP8 P22894 1/20 0.37
ALDH1A1 P00352 1/20 0.37
PKM P14618 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
DPP4 P27487 1/20 0.37
EPHX1 P07099 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7274093 1.00 PPARG (0.41) PPARGPPARAHTR2AHTR2CHTR2B
SCHEMBL7550711 0.84 PKM (0.50) PPARGPPARAALDH1A1PKMSMN1; SMN2
SCHEMBL7550706 0.84 PKM (0.50) PPARGPPARAALDH1A1PKMSMN1; SMN2
SCHEMBL7267958 0.80 LDHA (0.46) PPARGPPARAPPARDALDH1A1EPHX1
SCHEMBL7267954 0.80 LDHA (0.46) PPARGPPARAPPARDALDH1A1EPHX1
SCHEMBL28700052 0.80 PPARG (0.43) PPARGPPARAMMP1ALDH1A1PKM
SCHEMBL28700053 0.80 PPARG (0.43) PPARGPPARAMMP1ALDH1A1PKM
SCHEMBL7267333 0.80 PPARG (0.39) PPARGPPARAMMP1PPARDALDH1A1
SCHEMBL7267340 0.80 PPARG (0.39) PPARGPPARAMMP1PPARDALDH1A1
SCHEMBL7267133 0.77 ACACB (0.40) PPARGPPARAALDH1A1PKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5620987-A Amino acid derivatives HOFFMANN-LA ROCHE INC. (US) 1997-04-15 US disclosed
US-5554756-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1996-09-10 US disclosed
EP-0346847-B1 Amino acid derivatives HOFFMANN LA ROCHE (CH) 1994-05-11 EP disclosed
US-5157041-A Viricides HOFFMANN-LA ROCHE INC. (US) 1992-10-20 US disclosed
EP-0346847-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1989-12-20 EP disclosed