Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379056 | 0.86 | CYP19A1 (0.39) | KDM4EALDH1A1HPGDCYP19A1RARB | |
| SCHEMBL10587563 | 0.79 | TYMS (0.38) | CYP19A1RARBRARGBACE1TYMS | |
| SCHEMBL6244091 | 0.79 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDRARBRARG | |
| SCHEMBL7268304 | 0.78 | BACE1 (0.33) | CYP19A1RARBRARGBACE1 | |
| SCHEMBL5764522 | 0.74 | PDE7A (0.46) | KDM4EALDH1A1HPGDRARBRARG | |
| SCHEMBL9379702 | 0.72 | MAPK1 (0.38) | ALDH1A1CYP19A1RARBRARGGAA | |
| SCHEMBL7297952 | 0.71 | CYP19A1 (0.36) | KDM4EALDH1A1HPGDCYP19A1RARB | |
| SCHEMBL3140413 | 0.69 | CA9 (0.53) | KDM4ECYP19A1RARBRARGBACE1 | |
| SCHEMBL17478594 | 0.69 | PDE7A (0.45) | ALDH1A1RARBRARGMEN1MAPT | |
| SCHEMBL6432532 | 0.69 | NR3C2 (0.56) | KDM4EALDH1A1HPGDNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322746-B1 | Heterocyclic compounds | ORION YHTYMAE OY (FI) | 1996-05-29 | — | — | EP | disclosed |
| US-4963677-A | TREATMENT OF CONGESTIVE HEART FAILURE | ORION CORPORATION LTD. (FI) | 1990-10-16 | — | — | US | disclosed |
| EP-0322746-A1 | Heterocyclic compounds | ORION CORPORATION LIMITED (FI) | 1989-07-05 | — | — | EP | disclosed |