Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707621 | 0.79 | CYP1A2 (0.43) | RAB9AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL1520828 | 0.79 | ALDH1A1 (0.53) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL3136961 | 0.79 | ALDH1A1 (0.53) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL3365048 | 0.78 | HDAC6 (0.49) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL28714141 | 0.78 | HDAC3 (0.50) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL7274371 | 0.78 | NPC1 (0.47) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL2107923 | 0.76 | NPC1 (0.57) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL271243 | 0.76 | RAB9A (0.50) | RAB9AKCNH2 | |
| SCHEMBL10198779 | 0.76 | ALDH1A1 (0.50) | NPC1POLBRAB9ADAOALDH1A1 | |
| SCHEMBL23930005 | 0.76 | HDAC3 (0.50) | NPC1POLBRAB9ADAOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |