Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272424 | 0.93 | SIGMAR1 (0.45) | SIGMAR1NAMPTNPC1RAB9AHDAC2 | |
| SCHEMBL7273654 | 0.91 | SIGMAR1 (0.44) | SIGMAR1NAMPTNPC1RAB9ACHRM4 | |
| SCHEMBL7283478 | 0.87 | SIGMAR1 (0.54) | SIGMAR1HDAC2HDAC8HDAC6LMNA | |
| Water SCHEMBL7275243 | 0.87 | KMT2A (0.40) | SIGMAR1CHRM4KDM1AOPRM1OPRD1 | |
| SCHEMBL7284329 | 0.86 | ACACB (0.41) | SIGMAR1OPRM1KDM4EPKM | |
| SCHEMBL7275657 | 0.86 | SIGMAR1 (0.46) | SIGMAR1NAMPTNPC1RAB9AHDAC8 | |
| SCHEMBL7274726 | 0.86 | SIGMAR1 (0.51) | SIGMAR1NAMPTHDAC2HDAC8HDAC6 | |
| SCHEMBL7273844 | 0.85 | SIGMAR1 (0.51) | SIGMAR1NAMPTHDAC8HDAC6LMNA | |
| SCHEMBL7274594 | 0.85 | SIGMAR1 (0.51) | SIGMAR1NAMPTHDAC8HDAC6LMNA | |
| SCHEMBL7275131 | 0.85 | SIGMAR1 (0.51) | SIGMAR1NAMPTHDAC8HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |