Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 15/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475037 | 0.88 | GPR119 (0.68) | GPR119PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7267828 | 0.88 | GPR119 (0.68) | GPR119PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7274638 | 0.87 | GPR119 (0.67) | GPR119PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7276577 | 0.84 | PDE3B (0.51) | GPR119PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7266897 | 0.84 | GPR119 (0.65) | GPR119PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7268118 | 0.83 | PDE3B (0.46) | GPR119PDE3BPDE3AALDH1A1MAPT | |
| SCHEMBL7266588 | 0.81 | GPR119 (0.59) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL2591658 | 0.79 | GPR119 (1.00) | GPR119 | |
| SCHEMBL7274513 | 0.77 | PDE3B (0.67) | GPR119PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL16156994 | 0.73 | PDE3B (0.72) | GPR119PDE3BPDE3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | claimed |
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0327800-A2 | 6-Phenyldihydro-3(2H)-pyridazinones, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-08-16 | — | — | EP | disclosed |