Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267828 | 0.89 | GPR119 (0.68) | GPR119PDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL10475037 | 0.89 | GPR119 (0.68) | GPR119PDE3BPDE3AMAPTMEN1 | |
| SCHEMBL16156994 | 0.87 | PDE3B (0.72) | GPR119PDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL16156986 | 0.87 | PDE3B (0.72) | GPR119PDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL7274554 | 0.87 | GPR119 (0.65) | GPR119PDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL7266897 | 0.85 | GPR119 (0.65) | GPR119PDE3BPDE3AMAPTMEN1 | |
| SCHEMBL7267737 | 0.80 | PDE3B (0.78) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL2591658 | 0.80 | GPR119 (1.00) | GPR119 | |
| SCHEMBL16156993 | 0.79 | PDE3B (1.00) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL30482759 | 0.79 | PDE3B (1.00) | GPR119PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0327800-A2 | 6-Phenyldihydro-3(2H)-pyridazinones, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-08-16 | — | — | EP | disclosed |