Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11119450 | 0.89 | KDM4E (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7274305 | 0.88 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11070583 | 0.87 | KDM4E (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11094768 | 0.83 | KDM4E (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL102433 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL3498584 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1HPGDPOLBMAPT | |
| SCHEMBL8564199 | 0.82 | MAPT (0.51) | KDM4EALDH1A1HPGDPOLBMAPT | |
| SCHEMBL1202722 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL7274828 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL10646314 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |