Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3498584 | 0.85 | KDM4E (0.49) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL11094584 | 0.85 | PPARG (0.57) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL11070583 | 0.84 | KDM4E (0.52) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL11094768 | 0.82 | KDM4E (0.50) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL7274580 | 0.82 | PSEN1 (0.57) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL1202722 | 0.81 | KDM4E (0.55) | MAPTRAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL8562316 | 0.81 | HSD11B1 (0.46) | CYP1A2 | |
| SCHEMBL10646314 | 0.80 | KDM4E (0.53) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL11119450 | 0.80 | KDM4E (0.48) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL11098397 | 0.80 | PPARG (0.52) | MAPTNPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596406-B1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5750699-A | HALOGENATING OF CORRESPONDING COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5574042-A | ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 1996-11-12 | — | — | US | disclosed |
| EP-0596406-A1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |