Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ATP4A | P20648 | 3/20 | 0.50 |
| ▸ | ATP4B | P51164 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PPIA | P62937 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094768 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1HPGDATP4AATP4B | |
| SCHEMBL3498584 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1HPGDPOLBGABRA2 | |
| SCHEMBL11098397 | 0.89 | PPARG (0.52) | KDM4EALDH1A1HPGDATP4AATP4B | |
| SCHEMBL7274580 | 0.87 | PSEN1 (0.57) | KDM4EALDH1A1HPGDPOLBGABRA2 | |
| SCHEMBL11096196 | 0.86 | ATP4A (0.50) | ATP4AATP4BHRH3PSEN1PSEN2 | |
| SCHEMBL11094584 | 0.85 | PPARG (0.57) | KDM4EALDH1A1HPGDPOLBGABRA2 | |
| SCHEMBL11099677 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1HPGDPOLBPSEN1 | |
| SCHEMBL11119450 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1HPGDPOLBGABRA2 | |
| SCHEMBL8564199 | 0.84 | MAPT (0.51) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL1202722 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDPOLBGABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033094-B1 | IMIDAZO(1,2-A)PYRIDINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1984-10-10 | — | — | EP | disclosed |
| US-4450164-A | ANTIULCER AND ANTISECRETORY AGENTS | SCHERING CORPORATION (US) | 1984-05-22 | — | — | US | disclosed |
| EP-0033094-A1 | Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-08-05 | — | — | EP | disclosed |