Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | CTSE | P14091 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274657 | 0.82 | REN (0.60) | RENCTSDCTSE | |
| SCHEMBL10768949 | 0.81 | CYP1A2 (0.51) | RENCTSDCTSECYP1A2ALDH1A1 | |
| SCHEMBL10768958 | 0.79 | REN (0.51) | RENKLK5 | |
| SCHEMBL7285400 | 0.79 | CA1 (0.44) | RENCTSDCTSEPSEN1PSEN2 | |
| SCHEMBL7289460 | 0.79 | CA1 (0.44) | RENCTSDCTSEPSEN1PSEN2 | |
| SCHEMBL9725793 | 0.79 | CA1 (0.44) | RENCTSDCTSEPSEN1PSEN2 | |
| SCHEMBL9725761 | 0.79 | CA1 (0.44) | RENCTSDCTSEPSEN1PSEN2 | |
| SCHEMBL7289457 | 0.79 | CA1 (0.44) | RENCTSDCTSEPSEN1PSEN2 | |
| SCHEMBL28583822 | 0.78 | PTPRA (0.46) | RENCTSDCTSECYP1A2APP | |
| SCHEMBL28583820 | 0.78 | PTPRA (0.46) | RENCTSDCTSECYP1A2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360791-A | Renin-inhibiting aminodiol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0370454-B1 | Renin-inhibiting amino diol derivatives | HOECHST AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |