Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.60 |
| ▸ | CTSD | P07339 | 1/20 | 0.60 |
| ▸ | CTSE | P14091 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512616 | 0.94 | REN (0.61) | RENCTSDCTSE | |
| SCHEMBL9513094 | 0.87 | REN (0.62) | RENCTSDCTSE | |
| SCHEMBL7297120 | 0.82 | REN (0.63) | RENCTSD | |
| SCHEMBL7274775 | 0.82 | REN (0.46) | RENCTSDCTSE | |
| SCHEMBL7277872 | 0.81 | REN (0.44) | RENCTSDCTSE | |
| SCHEMBL9725818 | 0.81 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9739264 | 0.81 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9725825 | 0.81 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9725812 | 0.81 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL10408937 | 0.80 | REN (0.57) | RENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417698-B1 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| US-5360791-A | Renin-inhibiting aminodiol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0370454-B1 | Renin-inhibiting amino diol derivatives | HOECHST AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| EP-0519434-A2 | Heterocyclic compounds with renin inhibiting properties, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-12-23 | — | — | EP | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |
| EP-0394853-A1 | Dipeptide-derivatives with enzym-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-10-31 | — | — | EP | disclosed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |