Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275016 | 1.00 | KMT2A (0.50) | KMT2AL3MBTL1KCNA3MAPK1NAMPT | |
| SCHEMBL7296868 | 0.90 | MAPT (0.50) | KMT2AL3MBTL1KCNA3MAPK1NAMPT | |
| SCHEMBL9326303 | 0.90 | MAPT (0.50) | KMT2AL3MBTL1KCNA3MAPK1NAMPT | |
| SCHEMBL7298127 | 0.86 | KDM4E (0.52) | KMT2AMAPK1DRD2CKS1BSKP1 | |
| SCHEMBL7298121 | 0.86 | KDM4E (0.52) | KMT2AMAPK1DRD2CKS1BSKP1 | |
| SCHEMBL7294982 | 0.86 | CTSS (0.46) | KMT2AL3MBTL1KCNA3NAMPTDRD2 | |
| SCHEMBL7294978 | 0.86 | CTSS (0.46) | KMT2AL3MBTL1KCNA3NAMPTDRD2 | |
| SCHEMBL7304024 | 0.82 | KMT2A (0.52) | KMT2AL3MBTL1KCNA3MAPK1DRD2 | |
| SCHEMBL7304028 | 0.82 | KMT2A (0.52) | KMT2AL3MBTL1KCNA3MAPK1DRD2 | |
| SCHEMBL7298317 | 0.82 | KMT2A (0.48) | KMT2AL3MBTL1KCNA3MAPK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712417-A | Inhibitors of retroviral proteases | ABBOTT LABORATORIES (US) | 1998-01-27 | — | — | US | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0410278-B1 | Renin inhibiting aminooligohydroxy-derivatives | HOECHST AG (DE) | 1994-01-19 | — | — | EP | disclosed |
| WO-1992007845-A1 | DERIVATIVES OF AMINO ACIDS AS INHIBITORS OF RENIN, METHODS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-14 | — | — | WO | disclosed |
| EP-0483403-A1 | Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |
| EP-0410278-A1 | Renin inhibiting aminooligohydroxy-derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-01-30 | — | — | EP | disclosed |