Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298121 | 1.00 | KDM4E (0.52) | KDM4EPKMKMT2AATMCKS1B | |
| SCHEMBL7306403 | 0.91 | KDM4E (0.48) | KDM4EPKMKMT2AATMCKS1B | |
| SCHEMBL7303915 | 0.86 | CTSS (0.47) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL7303917 | 0.86 | CTSS (0.47) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL7275022 | 0.86 | KMT2A (0.50) | KMT2ACKS1BSKP1SKP2DRD2 | |
| SCHEMBL7275016 | 0.86 | KMT2A (0.50) | KMT2ACKS1BSKP1SKP2DRD2 | |
| SCHEMBL7304465 | 0.82 | KDM4E (0.57) | KDM4EPKMKMT2AATMCKS1B | |
| SCHEMBL7304469 | 0.82 | KDM4E (0.57) | KDM4EPKMKMT2AATMCKS1B | |
| SCHEMBL7305620 | 0.80 | CTSS (0.43) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL9326499 | 0.80 | CTSS (0.43) | KDM4EPKMCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417698-B1 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |