Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275020 | 1.00 | KMT2A (0.45) | KMT2AMEN1CRBNSMN1; SMN2LMNA | |
| SCHEMBL8534565 | 0.84 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2LMNAGAA | |
| SCHEMBL8534561 | 0.82 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2LMNAGAA | |
| SCHEMBL4374441 | 0.78 | CRBN (0.50) | CRBNSMN1; SMN2LMNANPC1NR2F2 | |
| SCHEMBL9621854 | 0.74 | HCRTR2 (0.45) | ALDH1A1CYP2C9CYP2C19TSHR | |
| SCHEMBL6703838 | 0.74 | TP53 (0.46) | ALDH1A1CYP3A4CYP2C19TSHR | |
| SCHEMBL27091866 | 0.74 | KMT2A (0.58) | KMT2AMEN1LMNAGAAALDH1A1 | |
| SCHEMBL16509689 | 0.73 | MTNR1A (0.47) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL30829326 | 0.73 | HCRTR1 (0.47) | CYP3A4CYP2C19TSHR | |
| SCHEMBL7275111 | 0.73 | HCRTR1 (0.47) | CYP3A4CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381959-B1 | Cyclohexaneacetamide derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-03 | — | — | EP | disclosed |
| US-5015653-A | Posess Cognitive Enhancement And Antiamnestic Activity | HOFFMANN-LA ROCHE INC. (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0381959-A1 | Cyclohexaneacetamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-16 | — | — | EP | disclosed |