Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065133 | 0.87 | HCRTR1 (0.42) | HCRTR2HCRTR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL22453807 | 0.85 | HCRTR2 (0.51) | HCRTR2HCRTR1TP53MDM2P2RX7 | |
| SCHEMBL8534565 | 0.84 | KMT2A (0.45) | HCRTR2HCRTR1ALDH1A1CYP2C9TSHR | |
| SCHEMBL27939222 | 0.81 | HCRTR1 (0.44) | HCRTR2HCRTR1TP53MDM2P2RX7 | |
| SCHEMBL27939223 | 0.81 | HCRTR1 (0.44) | HCRTR2HCRTR1TP53MDM2P2RX7 | |
| SCHEMBL6703838 | 0.78 | TP53 (0.46) | HCRTR2HCRTR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL1649644 | 0.78 | KCNA5 (0.38) | P2RX7 | |
| SCHEMBL7282645 | 0.77 | HCRTR2 (0.42) | HCRTR2HCRTR1TP53MDM2P2RX7 | |
| SCHEMBL8881593 | 0.77 | HCRTR2 (0.42) | HCRTR2HCRTR1TP53MDM2P2RX7 | |
| SCHEMBL16509689 | 0.77 | MTNR1A (0.47) | HCRTR2HCRTR1ALDH1A1TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149808-A | Nootropics, antihypoxic agents | BOEHRINGER INGELHEIM KG (DE) | 1992-09-22 | — | — | US | disclosed |
| EP-0266563-B1 | USE OF 1-BENZYL-AMINO-ALKYL-PYRROLIDINONES AS ANTIDEPRESSANTS | BOEHRINGER INGELHEIM KG (DE) | 1992-01-29 | — | — | EP | disclosed |
| US-5073671-A | Nootropic and antihypoxic agents | BOEHRINGER INGELHEIM KG (DE) | 1991-12-17 | — | — | US | disclosed |
| US-4996224-A | 1-benzyl-4- or 5-pyrrolidinomethyl-pyrrolidin-2-ones and nootropic method of use thereof | BOEHRINGER INGELHEIM KG (DE) | 1991-02-26 | — | — | US | disclosed |
| US-4954516-A | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1990-09-04 | — | — | US | disclosed |
| US-4912129-A | Administering to humans | BOEHRINGER INGELHEIM GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| US-4833140-A | ANTIHYPOXIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0136658-B1 | -1-BENZYL-AMINOALKYL-PYRROLIDINONES AND THEIR ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | BOEHRINGER INGELHEIM KG (DE) | 1989-04-26 | — | — | EP | disclosed |
| US-4812453-A | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1989-03-14 | — | — | US | disclosed |
| US-4767759-A | ANTIHYPOXICS | BOEHRINGER INGELHEIM KG (DE) | 1988-08-30 | — | — | US | disclosed |
| EP-0266563-A2 | Use of 1-benzyl-amino-alkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1988-05-11 | — | — | EP | disclosed |
| EP-0136658-A2 | -1-Benzyl-aminoalkyl-pyrrolidinones and their addition salts, process for their preparation and pharmaceutical compounds containing them | BOEHRINGER INGELHEIM KG (DE) | 1985-04-10 | — | — | EP | disclosed |