Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.58 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.58 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.58 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7275998 | 1.00 | HTR3A (0.58) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7268699 | 0.91 | HTR3A (0.60) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7268689 | 0.91 | HTR3A (0.60) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270753 | 0.88 | HTR3A (0.59) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270744 | 0.88 | HTR3A (0.59) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270674 | 0.87 | HTR3A (0.57) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270689 | 0.87 | HTR3A (0.57) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270760 | 0.85 | HTR3A (0.55) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270309 | 0.85 | HTR3A (0.54) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 | |
| Fumaric Acid SCHEMBL7270297 | 0.85 | HTR3A (0.54) | HTR3ACYP1A2KCNH2HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407137-B1 | Benzazine compounds and pharmaceutical uses thereof | YOSHITOMI PHARMACEUTICAL (JP) | 1996-05-01 | — | — | EP | disclosed |
| EP-0407137-A2 | Benzazine compounds and pharmaceutical uses thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-01-09 | — | — | EP | disclosed |