Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252929 | 1.00 | REN (0.49) | RENMETAP2ALDH1A1KMT2ADPP7 | |
| SCHEMBL7290166 | 0.98 | REN (0.47) | RENMETAP2ALDH1A1KMT2ADPP7 | |
| SCHEMBL7283961 | 0.98 | REN (0.47) | RENMETAP2ALDH1A1KMT2ADPP7 | |
| SCHEMBL7289862 | 0.87 | REN (0.46) | RENMETAP2ALDH1A1KMT2ADPP7 | |
| SCHEMBL7280570 | 0.87 | REN (0.46) | RENMETAP2ALDH1A1KMT2ADPP7 | |
| SCHEMBL7283265 | 0.86 | REN (0.49) | REN | |
| SCHEMBL8909805 | 0.84 | REN (0.56) | RENMETAP2 | |
| SCHEMBL7276949 | 0.84 | REN (0.56) | RENMETAP2 | |
| SCHEMBL9256057 | 0.84 | REN (0.56) | RENMETAP2 | |
| SCHEMBL7429514 | 0.76 | REN (0.43) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509354-B1 | Amino acid derivatives | HOFFMANN LA ROCHE (CH) | 2000-08-23 | — | — | EP | disclosed |
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0509354-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-21 | — | — | EP | disclosed |