Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.56 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276949 | 1.00 | REN (0.56) | RENFNTAFNTBPGGT1BP2RX1 | |
| SCHEMBL9256057 | 1.00 | REN (0.56) | RENFNTAFNTBPGGT1BP2RX1 | |
| SCHEMBL9800557 | 0.86 | REN (0.61) | RENFNTAFNTBPGGT1BP2RX1 | |
| SCHEMBL7276448 | 0.84 | REN (0.49) | RENMETAP2 | |
| SCHEMBL9252929 | 0.84 | REN (0.49) | RENMETAP2 | |
| SCHEMBL7290166 | 0.81 | REN (0.47) | RENMETAP2 | |
| SCHEMBL7283961 | 0.81 | REN (0.47) | RENMETAP2 | |
| SCHEMBL8908872 | 0.80 | REN (0.44) | RENP2RX1TSHR | |
| SCHEMBL7429514 | 0.79 | REN (0.43) | RENP2RX1PSEN1PSEN2APH1B | |
| SCHEMBL9279210 | 0.77 | REN (0.47) | RENP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |