Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042030 | 0.80 | BACE1 (0.52) | — | |
| SCHEMBL3042249 | 0.80 | BACE1 (0.52) | — | |
| SCHEMBL3049388 | 0.80 | BACE1 (0.52) | — | |
| SCHEMBL3046920 | 0.80 | BACE1 (0.52) | — | |
| SCHEMBL6942559 | 0.78 | NPC1 (0.45) | NPC1RAB9ACYP1A2SMN1; SMN2 | |
| SCHEMBL6942561 | 0.78 | NPC1 (0.45) | NPC1RAB9ACYP1A2SMN1; SMN2 | |
| SCHEMBL6945454 | 0.78 | NPC1 (0.45) | NPC1RAB9ACYP1A2SMN1; SMN2 | |
| SCHEMBL6942553 | 0.78 | NPC1 (0.45) | NPC1RAB9ACYP1A2SMN1; SMN2 | |
| SCHEMBL4728419 | 0.77 | NPC1 (0.50) | NPC1RAB9ACYP1A2 | |
| SCHEMBL7282595 | 0.77 | LMNA (0.47) | LMNATDP1NPC1RAB9APSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509354-B1 | Amino acid derivatives | HOFFMANN LA ROCHE (CH) | 2000-08-23 | — | — | EP | disclosed |
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0543245-A1 | Renin inhibiting amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-05-26 | — | — | EP | disclosed |
| EP-0509354-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-21 | — | — | EP | disclosed |