Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IL6ST | P40189 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274641 | 0.87 | POLB (0.54) | POLBHTTOXER1ALDH1A1RECQL | |
| SCHEMBL7276942 | 0.85 | OXER1 (0.42) | HTTOXER1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL27385284 | 0.82 | POLB (0.43) | POLBHTTOXER1ALDH1A1RECQL | |
| SCHEMBL10359905 | 0.79 | HTT (0.51) | POLBHTTOXER1ALDH1A1IL6ST | |
| SCHEMBL30569636 | 0.77 | L3MBTL1 (0.63) | POLBOXER1L3MBTL1IL6STCREBBP | |
| SCHEMBL3165284 | 0.77 | L3MBTL1 (0.63) | POLBOXER1L3MBTL1IL6STCREBBP | |
| SCHEMBL16145665 | 0.74 | POLB (0.52) | POLBALDH1A1 | |
| SCHEMBL28319256 | 0.73 | L3MBTL1 (0.41) | OXER1ALDH1A1RECQLL3MBTL1IL6ST | |
| SCHEMBL29424269 | 0.72 | HTR2A (0.59) | POLBHTTOXER1ALDH1A1MAPT | |
| SCHEMBL12775639 | 0.72 | CREBBP (0.48) | POLBHTTALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512831-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1999-09-22 | — | — | EP | disclosed |
| EP-0478362-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1999-06-09 | — | — | EP | disclosed |
| EP-0512829-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| US-5455243-A | Anticoagulants | MERCK & CO., INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5321034-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1994-06-14 | — | — | US | disclosed |
| US-5281585-A | Secondary amide containing antagonist | MERCK & CO., INC. (US) | 1994-01-25 | — | — | US | disclosed |
| US-5264420-A | Anticoagulants | MERCK & CO., INC. (US) | 1993-11-23 | — | — | US | disclosed |
| WO-1992019595-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512831-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0478362-A2 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | disclosed |