Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.49 |
| ▸ | CCR2 | P41597 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509653 | 0.90 | ROCK2 (0.48) | ROCK2ROCK1CCR2 | |
| SCHEMBL1509607 | 0.90 | ROCK2 (0.48) | ROCK2ROCK1CCR2 | |
| SCHEMBL528761 | 0.87 | ROCK2 (0.63) | ROCK2ROCK1CCR2 | |
| SCHEMBL727699 | 0.83 | ROCK2 (0.46) | ROCK2ROCK1CCR2 | |
| SCHEMBL4428205 | 0.83 | ROCK2 (0.61) | ROCK2ROCK1CCR2 | |
| SCHEMBL4428211 | 0.83 | ROCK2 (0.61) | ROCK2ROCK1CCR2 | |
| SCHEMBL13633468 | 0.78 | ROCK2 (0.62) | ROCK2ROCK1CCR2 | |
| SCHEMBL528598 | 0.77 | ROCK2 (0.54) | ROCK2ROCK1CCR2 | |
| SCHEMBL659539 | 0.77 | ROCK2 (0.54) | ROCK2ROCK1CCR2 | |
| SCHEMBL23360612 | 0.77 | ROCK2 (0.48) | ROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524909-A | — | — | 2011-09-08 | — | — | JP | claimed |
| EP-2291077-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | Inspire Pharmaceuticals, Inc. (US) | 2011-03-09 | — | — | EP | claimed |
| WO-2009154940-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | claimed |
| EP-2291077-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | Inspire Pharmaceuticals, Inc. (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009154940-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |