Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.71 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274376 | 0.88 | ADORA2A (0.68) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2294590 | 0.83 | ADORA2A (1.00) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL5226057 | 0.82 | ADORA2A (0.56) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL30082250 | 0.81 | ADORA2A (0.86) | ADORA2AADORA2B | |
| SCHEMBL7269959 | 0.80 | ADORA2A (0.80) | ADORA2AADORA2B | |
| SCHEMBL8127160 | 0.79 | ADORA2A (0.67) | ADORA2AADORA2B | |
| SCHEMBL7269624 | 0.78 | ADORA2A (0.88) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL5227560 | 0.77 | ADORA1 (0.90) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL9645551 | 0.75 | ADORA1 (0.95) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL8118476 | 0.75 | ADORA1 (1.00) | ADORA2AADORA2BADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386675-B1 | Xanthine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5068236-A | Diuretics, renal protective agents and hypotensives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0386675-A2 | Xanthine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |